Effect of aspartate and glutamate on carbon tetrachloride induced liver damage in rats.
Indian J Exp Biol
;
1990 Dec; 28(12): 1180-3
Artigo
em Inglês
| IMSEAR
| ID: sea-57274
ABSTRACT
Liver necrosis was produced in rats by administering 3 doses of a mixture of carbon tetrachloride + olive oil, 2 ml/kg, ip. The liver damage was evidenced by the elevated levels of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) and gamma glutamyl transpeptidase (gamma-GT) and by histopathological observations of liver sections. Aspartate and glutamate administration (100 mg/kg, ip) significantly reduced these elevated levels of AST, ALT, and gamma-GT. Carbon tetrachloride induced liver necrosis was also found to be significantly reduced in aspartate and glutamate pretreated animals as observed macroscopically and histologically.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Ratos
/
Ratos Endogâmicos
/
Masculino
/
Tetracloreto de Carbono
/
Ácido Aspártico
/
Glutamatos
/
Hepatopatias
/
Animais
/
Necrose
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
1990
Tipo de documento:
Artigo
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