N-Phthaloyl gamma-aminobutyric acid affects biochemical circadian rhythms in Wistar rats.
Indian J Exp Biol
;
2001 Apr; 39(4): 360-4
Artigo
em Inglês
| IMSEAR
| ID: sea-57480
ABSTRACT
N-Phthaloyl gamma-aminobutyric acid (P-GABA) was administered to Wistar rats and 24 hr rhythms of glucose, cholesterol, total protein and lactic acid levels in blood were studied under semi-natural light dark conditions. P-GABA administration caused desynchronisation of the rhythms; while glucose and lactic acid rhythms were advanced, cholesterol and total protein rhythms were delayed. Since GABA is being involved in conveying dark information to the clock, exogenous administration of P-GABA may reduce the photic information received by the clock. The results could be explained by slightly less than 1 hr daily delays (or) advances respectively which would bring the peak times to the points 21 days after the start of administration.
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Índice:
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Assunto principal:
Ratos
/
Glicemia
/
Masculino
/
Proteínas Sanguíneas
/
Colesterol
/
Ritmo Circadiano
/
Ratos Wistar
/
Fotoperíodo
/
Agonistas GABAérgicos
/
Ácido Láctico
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
2001
Tipo de documento:
Artigo
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