Subchronic oral hepatotoxicity of turmeric in mice--histopathological and ultrastructural studies.
Indian J Exp Biol
;
1998 Jul; 36(7): 675-9
Artigo
em Inglês
| IMSEAR
| ID: sea-57506
ABSTRACT
Dietary administration of the whole spice turmeric (0.2%, 1.0%, 5.0%) or ethanolic turmeric extract (ETE, 0.05%, 0.25%) for 14 days, at doses reported to be cancer preventive in model systems, were found to be hepatotoxic in mice. Histopathological evaluation showed coagulative necrosis accompanied by a zone of regenerating parenchymal cells of liver. The ultrastructural changes in liver parenchymal cells were non-specific reaction to injury. Results suggest mouse to be a susceptible species for turmeric induced toxicity.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Feminino
/
Extratos Vegetais
/
Microscopia Eletrônica
/
Administração Oral
/
Condimentos
/
Curcuma
/
Doença Hepática Induzida por Substâncias e Drogas
/
Animais
/
Camundongos
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
1998
Tipo de documento:
Artigo
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