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Inhibitory effect of manganese on contraction of isolated rat aorta.
Indian J Exp Biol ; 2004 Feb; 42(2): 149-51
Artigo em Inglês | IMSEAR | ID: sea-57523
ABSTRACT
The effects of MnCl2 on vascular smooth muscle contraction induced by noradrenaline (NA) and KCl were investigated. Rings segments from rat aorta were isolated and changes in isometric tension recorded. MnCl2 (10 microM and 1 mM) significantly attenuated the contractile responses to NA and KCI. There were also reductions in the contractile responses to CaCl2 in NA- and KCl-stimulated rings, after pretreatment with MnCl2. The magnitude of the phasic contraction to NA was significantly reduced in presence of MnCl2. The results suggest that MnCl2 inhibits vascular smooth muscle contraction by influencing a Ca2+-mediated mechanism.
Assuntos
Texto completo: DisponíveL Índice: IMSEAR (Sudeste Asiático) Assunto principal: Aorta Torácica / Cloreto de Potássio / Ratos / Vasoconstritores / Norepinefrina / Cloretos / Cálcio / Ratos Sprague-Dawley / Compostos de Manganês / Animais Idioma: Inglês Revista: Indian J Exp Biol Ano de publicação: 2004 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: IMSEAR (Sudeste Asiático) Assunto principal: Aorta Torácica / Cloreto de Potássio / Ratos / Vasoconstritores / Norepinefrina / Cloretos / Cálcio / Ratos Sprague-Dawley / Compostos de Manganês / Animais Idioma: Inglês Revista: Indian J Exp Biol Ano de publicação: 2004 Tipo de documento: Artigo