Effect of oral magnesium supplementation on experimental pre-eclampsia induced by prolonged blockade of nitric oxide synthesis in pregnant rats.
Indian J Exp Biol
;
2002 Mar; 40(3): 349-51
Artigo
em Inglês
| IMSEAR
| ID: sea-57614
ABSTRACT
Nitric oxide inhibitor L-NAME when given alone caused a significant rise in both systolic and diastolic pressure, an increase in 24 hr urinary protein excretion and reduction in weight of the litter as compared to control group. Supplementation of MgSO4 at lower dose (250 mg/kg) did not inhibit this pre-eclamptic effect of L-NAME; but in higher doses (500 and 750 mg/kg), it inhibited the pre-eclamptic action of L-NAME. The results suggest that administration of MgSO4 improves the foetal outcome and significantly prevents the development of symptoms of pre-eclampsia like hypertension and proteinuria.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Pré-Eclâmpsia
/
Proteinúria
/
Ratos
/
Pressão Sanguínea
/
Feminino
/
Gravidez
/
Administração Oral
/
Ratos Wistar
/
Óxido Nítrico Sintase
/
NG-Nitroarginina Metil Éster
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
2002
Tipo de documento:
Artigo
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