Protective effect of coleonol on biochemical changes produced in coronary ligation induced ischemia.
Indian J Exp Biol
;
1990 Oct; 28(10): 981-4
Artigo
em Inglês
| IMSEAR
| ID: sea-57626
ABSTRACT
Coleonol, a diterpine prevented biochemical changes induced by coronary artery ligation in rabbits at a dose of 10 mg/kg, iv. It increased the heart mitochondrial oxygen uptake and O ratio, which may be responsible for the stabilization of heart membrane. The decrease in serum creatine phosphokinase, glutamate oxaloacetate transaminase, glutamate pyruvate transaminase phospholipase and lipid peroxide and increase in cytochrome P450, glycogen and superoxide dismutase activity by coleonol treatment could have contributed to restore myocardial integrity and cardiac function disturbed by coronary artery ligation. The cardioprotective activity of coleonol was found to be comparable to propranolol.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Consumo de Oxigênio
/
Propranolol
/
Coelhos
/
Colforsina
/
Doença das Coronárias
/
Vasos Coronários
/
Enzimas
/
Ligadura
/
Animais
/
Mitocôndrias Cardíacas
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
1990
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS