Modulation of serum cortisol by substance P in albino rats: evidence of a direct effect on adrenal gland.
Indian J Exp Biol
;
2006 Feb; 44(2): 163-4
Artigo
em Inglês
| IMSEAR
| ID: sea-57697
ABSTRACT
Effect of prolonged administration of substance P on the plasma cortisol level in the albino rats has been investigated. An inhibitory impact on intact individuals and a stimulatory effect in pharmacologically annulled rats has been observed. It is concluded that in normal conditions substance P presumably acts as a preventive agent for any excess secretion of cortisol while during stress or disturbed HPA or RAS conditions, it stimulates the secretion of cortisol. An intraglandular modulatory role of substance P has been suggested.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Ratos
/
Estresse Fisiológico
/
Hidrocortisona
/
Substância P
/
Glândulas Suprarrenais
/
Neurotransmissores
/
Sistema Hipotálamo-Hipofisário
/
Injeções Subcutâneas
/
Animais
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
2006
Tipo de documento:
Artigo
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