Pulmonary phospholipid changes induced by butylated hydroxy toluene, an antioxidant, in rats.
Indian J Exp Biol
;
1995 Oct; 33(10): 796-7
Artigo
em Inglês
| IMSEAR
| ID: sea-57714
ABSTRACT
Butylated hydroxy toluene (BHT), 800 mg/kg body weight, dissolved in corn oil and administered (ip) in a single injection to male rats, damaged the lung as indicated by an increase in lavage ACE, protein and LDH and caused a significant increase in phospholipid, particularly, phosphatidyl choline (PC) in lung lavage and extracellular surfactant. The plasma lecithin cholesterol acyl transferase (LCAT) activity was inhibited leading to an increase in serum phospholipids and phosphatidyl choline. The results indicate that BHT-induced lung phospholipidosis may be attributed to an increase in surfactant phospholipids and/or due to the leakage of plasma phospholipids through damaged capillary membrane.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Fosfolipídeos
/
Ratos
/
Masculino
/
Hidroxitolueno Butilado
/
Ratos Wistar
/
Aditivos Alimentares
/
Pulmão
/
Animais
/
Antioxidantes
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
1995
Tipo de documento:
Artigo
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