Radiosensitizing effect of plumbagin on mouse melanoma cells grown in vitro.
Indian J Exp Biol
;
1996 Sep; 34(9): 857-8
Artigo
em Inglês
| IMSEAR
| ID: sea-57800
ABSTRACT
Mouse melanoma cells were treated with plumbagin, a naphthoquinone, from the plant Plumbago rosea at 0.5 microgram/ml (PI) for 60 min either alone or followed by 2 Gy gamma radiation (RT). Response to the different treatments was assessed by following the cell growth up to 5 days post treatment. PI alone produced a significant decrease in the cell count on days 3 and 4, whereas RT treatment significantly enhanced the growth inhibitory effect when compared to RT or PI alone. These findings suggests the radiosensitizing effect of PI on mouse melanoma cells in vitro, supporting the earlier in vivo findings.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Radiossensibilizantes
/
Melanoma Experimental
/
Células Tumorais Cultivadas
/
Divisão Celular
/
Naftoquinonas
/
Animais
/
Camundongos
/
Camundongos Endogâmicos C57BL
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
1996
Tipo de documento:
Artigo
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