Effect of ricin on acute phase response in rats.
Indian J Exp Biol
;
1991 Jun; 29(6): 584-5
Artigo
em Inglês
| IMSEAR
| ID: sea-57824
ABSTRACT
Ricin, a highly toxic protein from castor beans was administered (ip) to rats in a dose of 1.25 micrograms/100 g to selectively deplete at least 60-70% of Kupffer cells. This dose spared hepatocytes. This rat model was used to study acute phase protein synthesis and the role of Kupffer cells in acute phase response (APR). Ricin itself induced an APR, similar in pattern but of lower magnitude, than that induced by turpentine. However, the effect of combination of ricin and turpentine on APR was not additive. Kupffer cells appear to play permissive role in APR through mediators like hepatocytes stimulating factors.
Texto completo:
DisponíveL
Índice:
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Assunto principal:
Ratos
/
Ricina
/
Proteínas de Fase Aguda
/
Reação de Fase Aguda
/
Modelos Animais de Doenças
/
Células de Kupffer
/
Animais
Tipo de estudo:
Estudo prognóstico
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
1991
Tipo de documento:
Artigo
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