Ondansetron amelioration of scopolamine induced cognitive deficits in three-panel runway apparatus in rats.
Indian J Exp Biol
;
2004 Sep; 42(9): 919-21
Artigo
em Inglês
| IMSEAR
| ID: sea-57863
ABSTRACT
Effect of ondansetron (5-HT3-receptor antagonist) was studied on the working memory deficits induced by scopolamine, a muscarinic receptor antagonist in rats using a three-panel runway apparatus. Varying doses of scopolamine (0.1-0.56mg/kg, ip) were administered alone or in combination with ondansetron (0.01-1.0 mg/kg, ip) and memory errors and latency period of the session were recorded on a three-panel runway apparatus. Treatment with scopolamine (0.56 mg/kg) produced working memory deficits in rats. Treatment with ondansetron (1.0 mg/kg) significantly reduced the scopolamine-induced working memory deficits.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Ratos
/
Escopolamina
/
Antagonistas da Serotonina
/
Masculino
/
Ratos Wistar
/
Ondansetron
/
Antagonistas Muscarínicos
/
Animais
/
Memória
/
Transtornos da Memória
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
2004
Tipo de documento:
Artigo
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