Evaluation of methanolic extract of Ficus platyphylla on gastrointestinal activity.
Indian J Exp Biol
;
2001 Jan; 39(1): 63-7
Artigo
em Inglês
| IMSEAR
| ID: sea-57938
ABSTRACT
Methanolic extract of Ficus platyphylla was tested on isolated rabbit jejunum, rat duodenum and gastrointestinal motility in mice. The extract showed a biphasic effect on isolated smooth muscle. Lower concentration of extract caused contraction, while higher concentrations produced relaxation. The contractile phase was attenuated by atropine, while relaxant phase attenuated histamine induced contraction of guinea pig ileum. The extract also exhibited a dose-dependent inhibition of gastrointestinal motility. Acute toxicity test in mice established LD50 value (i.p.) of the extract to be 2000 mg/kg. Preliminary phytochemical screening of the extract gave positive test for flavonoids, tannins and saponins.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Coelhos
/
Ratos
/
Feminino
/
Masculino
/
Trânsito Gastrointestinal
/
Extratos Vegetais
/
Ratos Wistar
/
Rosales
/
Sistema Digestório
/
Relação Dose-Resposta a Droga
Tipo de estudo:
Estudos de avaliação
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
2001
Tipo de documento:
Artigo
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