Effect of propriety herbal formulation against chronic carbon tetrachloride induced hepatotoxicity.
Indian J Exp Biol
;
2002 Nov; 40(11): 1254-9
Artigo
em Inglês
| IMSEAR
| ID: sea-58193
ABSTRACT
Efficacy of propriety herbal formulation (PHF) against carbon tetrachloride (CCl4) induced liver damage was investigated in adult rats. Administration of CCl4 (0.2 ml/kg; i.p.) twice a week for 12 weeks resulted in significant elevation in serum transaminases activity. Level of reduced glutathione was significantly decreased. On the contrary, significant elevation was found in the hepatic lipid peroxidation level. Proliferation of fibroblast replaced the hepatic parenchyma cells in focal areas. Cell organelles like mitochondria, endoplasmic reticulum and nucleus showed severe degeneration after CCl4 exposure. PHF was effective in restoring the CCl4 induced biochemical and histological ultrastructural changes.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Aspartato Aminotransferases
/
Ratos
/
Masculino
/
Tetracloreto de Carbono
/
Intoxicação por Tetracloreto de Carbono
/
Peroxidação de Lipídeos
/
Núcleo Celular
/
Ratos Sprague-Dawley
/
Preparações de Plantas
/
Alanina Transaminase
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
2002
Tipo de documento:
Artigo
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