Bioinorganic study on [Fe(promethazine)2H2O Cl]2+ complex.
Indian J Exp Biol
;
1998 Nov; 36(11): 1125-9
Artigo
em Inglês
| IMSEAR
| ID: sea-58285
ABSTRACT
The coordination chemistry of iron (III) is the environment of an antihistaminic drug, promethazine has been explained to include a low spin, six-coordinate complex [Fe(Prometha)2(H2O) Cl] Cl2. Metaldrug interaction in vitro in aqueous KCl phase was studied polarographically at physiological pH and temperature. On the basis of elemental, magnetic, conductometric, IR, UV-visible, NMR spectroscopic analysis it is concluded that in solid phase two promethazine molecules with their N,N donor sites encompass the metal. Mass spectral study on the complex confirms that one of the three chlorides is involved in the coordination. The respective changes in the antihistaminic activity of the drug as a result of complexation has been determined and a possible mechanism is suggested.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Prometazina
/
Espectrofotometria
/
Feminino
/
Masculino
/
Compostos Férricos
/
Espectroscopia de Ressonância Magnética
/
Avaliação Pré-Clínica de Medicamentos
/
Cobaias
/
Antagonistas dos Receptores Histamínicos H1
/
Animais
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
1998
Tipo de documento:
Artigo
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