Protective effect of ascorbic acid against oxidative stress induced by inorganic arsenic in liver and kidney of rat.
Indian J Exp Biol
;
2007 Apr; 45(4): 371-5
Artigo
em Inglês
| IMSEAR
| ID: sea-58293
ABSTRACT
Ascorbic acid treatment in arsenic trioxide treated rats increased arsenic excretion, inhibited lipid peroxidation, improved GSH status, regulated GSSG turnover and also restored glutathione-S-transferases activity in liver and kidney. Suitable mechanisms leading to ascorbic acid protection have been discussed. Upregulation of GSH dependent enzymes was found to be necessary for a protective effect. Protection is finally attributed to higher GSH levels observed in the liver and kidney of ascorbic acid and inorganic arsenic treated rats. It is also concluded that ascorbic acid protection is influenced by gender dependent factors. Arsenic poisoning is a global problem now. Gender differences need to be considered while applying therapeutic measures.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Arsênio
/
Ácido Ascórbico
/
Ratos
/
Feminino
/
Masculino
/
Ratos Wistar
/
Estresse Oxidativo
/
Rim
/
Fígado
/
Animais
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
2007
Tipo de documento:
Artigo
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