Morphine-like activity of some N-substituted amides of met-enkephalin.
Indian J Exp Biol
;
1989 Sep; 27(9): 826-8
Artigo
em Inglês
| IMSEAR
| ID: sea-58304
ABSTRACT
Opioid activity of a homologous series of met-enkephalin alkylamides was analysed. In guinea pig ileum test, the hexylamide derivative was most active, whereas the isopropylamide derivative was most potent in analgesia test. The results suggest that structural changes of this type at the C-terminus of the pentapeptide improve the opioid activity.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Encefalina Metionina
/
Química
/
Fenômenos Químicos
/
Amidas
/
Cobaias
/
Íleo
/
Animais
/
Morfina
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
1989
Tipo de documento:
Artigo
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