Antitumor and antifertility activities of plumbagin controlled release formulations.
Indian J Exp Biol
;
1997 Apr; 35(4): 374-9
Artigo
em Inglês
| IMSEAR
| ID: sea-58406
ABSTRACT
With a view to increase efficiency and reduce toxicity of Plumbagin, an attempt was made to formulate plumbagin as a controlled release preparation using various carriers and test for their antitumor and antifertility activities. Niosomes and albumin microspheres were used as carriers. In vitro data showed promising results for these formulations thus they were taken up for in vivo assessment. Given at a dose of 5 mg/kg, ip the albumin microspheres showed promising antitumor and antifertility activity when compared to the niosomes on control. Animal survival data also indicated slight improvement in survival rate and thus antitumoral activity. Also, an interesting point was that the antifertility activity was affected through an antiovulatory action as seen from histopathological studies.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Ovário
/
Ratos
/
Melanoma Experimental
/
Feminino
/
Masculino
/
Gravidez
/
Portadores de Fármacos
/
Naftoquinonas
/
Anticoncepcionais
/
Preparações de Ação Retardada
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
1997
Tipo de documento:
Artigo
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