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Liposomes of terbutaline sulphate: in vitro and in vivo studies.
Indian J Exp Biol ; 1999 Sep; 37(9): 881-7
Artigo em Inglês | IMSEAR | ID: sea-58437
ABSTRACT
In vitro studies were conducted to understand the comparative drug diffusion pattern, across artificial membrane, of the drug and of the prepared liposomes of different liposomal membrane composition. In vivo studies were carried out to determine the extent and time-course of pulmonary tissue uptake of administered liposomes containing terbutaline sulphate(TER) on rat lungs. In vitro studies revealed that the drug released from the prepared liposomes obeys Higuchi's diffusion controlled model. Different loading doses and release patterns of drug from the liposomes can be obtained by altering the PCCHOL ratio and incorporation of cholesterol was found to reduce permeability of the membrane. Similarly drug absorption in vivo in rat's lung following intratracheal instillation, prolonged over 12 hr by liposomal entrapment of TER. The findings of present investigation indicated that liposomally encapsulated TER can be used for pulmonary delivery for maximizing the therapeutic efficacy and reducing undesirable side effects.
Assuntos
Texto completo: DisponíveL Índice: IMSEAR (Sudeste Asiático) Assunto principal: Ratos / Terbutalina / Broncodilatadores / Portadores de Fármacos / Lipossomos / Animais Tipo de estudo: Estudo prognóstico Idioma: Inglês Revista: Indian J Exp Biol Ano de publicação: 1999 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: IMSEAR (Sudeste Asiático) Assunto principal: Ratos / Terbutalina / Broncodilatadores / Portadores de Fármacos / Lipossomos / Animais Tipo de estudo: Estudo prognóstico Idioma: Inglês Revista: Indian J Exp Biol Ano de publicação: 1999 Tipo de documento: Artigo