Nonspecific immunoprotection against Rous sarcoma tumor in chicks.
Indian J Exp Biol
;
1989 Jun; 27(6): 525-8
Artigo
em Inglês
| IMSEAR
| ID: sea-58611
ABSTRACT
An enzyme treated preparation of saprophytic Mycobacterium phlei, referred as NSI, when administered intramuscularly has been found to protect the chicks against Rous Sarcoma Virus induced tumor. A protection level of 35.4%, 24.1% and 21.2% were observed when challenged on 10th, 20th and 30th day post NSI inoculation. The tumor growth inhibitory-activity of NSI was significant (P less than 0.01). Both, systemic and intralesional administration of NSI exhibited significant tumorostatic activity (P less than 0.05). NSI stimulated the cell mediated immune response to specific as well as to nonspecific Rous sarcoma antigen. These studies indicated the immunopreventive activity of NSI against Rous sarcoma tumor which had an immunogenic basis.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Feminino
/
Masculino
/
Galinhas
/
Adjuvantes Imunológicos
/
Sarcoma Aviário
/
Vírus do Sarcoma Aviário
/
Imunidade Celular
/
Animais
/
Mycobacterium
/
Mycobacterium phlei
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
1989
Tipo de documento:
Artigo
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