Comparative gastrointestinal toxicity of selective cyclooxygenase (COX-2) inhibitors.
Indian J Exp Biol
;
2005 Jul; 43(7): 614-9
Artigo
em Inglês
| IMSEAR
| ID: sea-58781
ABSTRACT
Cyclooxygenase (COX-2) inhibitors were developed with the hope that they will cause fewer gastrointestinal adverse effects. Ability of selective as well as nonselective COX inhibitors to alter ischemia-reperfusion induced damage of gastric mucosa and hapten-induced colitis in rats has been compared. Celecoxib (10, 20 and 40 mg/kg(-l)) was significantly more potent at aggravating ischemia-reperfusion injury as compared to nimesulide. Similarly, celecoxib was found to maximally potentiate TNBS-induced colitis, followed by nimesulide and indomethacin. Celecoxib at its highest dose produced maximum deep histological injury. This paradoxic ulcer and colitis aggravating effect of selective COX-2 inhibitors may be explained by suppression of protective prostaglandins generated as a consequence of COX-2 induction in inflammatory states.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Pirazóis
/
Ratos
/
Sulfonamidas
/
Masculino
/
Traumatismo por Reperfusão
/
Indometacina
/
Inibidores de Ciclo-Oxigenase
/
Ratos Wistar
/
Colite
/
Trato Gastrointestinal
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
2005
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS