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Comparative gastrointestinal toxicity of selective cyclooxygenase (COX-2) inhibitors.
Indian J Exp Biol ; 2005 Jul; 43(7): 614-9
Artigo em Inglês | IMSEAR | ID: sea-58781
ABSTRACT
Cyclooxygenase (COX-2) inhibitors were developed with the hope that they will cause fewer gastrointestinal adverse effects. Ability of selective as well as nonselective COX inhibitors to alter ischemia-reperfusion induced damage of gastric mucosa and hapten-induced colitis in rats has been compared. Celecoxib (10, 20 and 40 mg/kg(-l)) was significantly more potent at aggravating ischemia-reperfusion injury as compared to nimesulide. Similarly, celecoxib was found to maximally potentiate TNBS-induced colitis, followed by nimesulide and indomethacin. Celecoxib at its highest dose produced maximum deep histological injury. This paradoxic ulcer and colitis aggravating effect of selective COX-2 inhibitors may be explained by suppression of protective prostaglandins generated as a consequence of COX-2 induction in inflammatory states.
Assuntos
Texto completo: DisponíveL Índice: IMSEAR (Sudeste Asiático) Assunto principal: Pirazóis / Ratos / Sulfonamidas / Masculino / Traumatismo por Reperfusão / Indometacina / Inibidores de Ciclo-Oxigenase / Ratos Wistar / Colite / Trato Gastrointestinal Idioma: Inglês Revista: Indian J Exp Biol Ano de publicação: 2005 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: IMSEAR (Sudeste Asiático) Assunto principal: Pirazóis / Ratos / Sulfonamidas / Masculino / Traumatismo por Reperfusão / Indometacina / Inibidores de Ciclo-Oxigenase / Ratos Wistar / Colite / Trato Gastrointestinal Idioma: Inglês Revista: Indian J Exp Biol Ano de publicação: 2005 Tipo de documento: Artigo