Involvement of potassium channels in hypoglycemic effect of sertraline.
Indian J Exp Biol
;
2006 Feb; 44(2): 120-2
Artigo
em Inglês
| IMSEAR
| ID: sea-58901
ABSTRACT
Effect of 21 days administration of sertraline (30 mg/kg, po) in streptozotocin (55 mg/kg, ip) induced diabetic and non-diabetic rats produced hypoglycemia in diabetic and non-diabetic rats. Pinacidil (1mg/kg, po), when co-administered with sertraline or glimepiride antagonized the decrease in glucose levels in diabetic rats. Pinacidil (10(-6)-10(-3) M) produced dose dependent relaxation (EC50-1.58 x 10(-5) M). Neither sertraline nor glimepiride had any effect on the resting tension of ileum preparation. Both sertraline and glimepiride antagonized competitively the pinacidil-induced relaxation. The pA2 values of sertraline and glimepiride reversal of pinacidil-induced relaxation were 5.5 and 6.2 respectively. These studies suggest the involvement of K+ channels in hypoglyceimic effects of sertraline.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Ratos
/
Compostos de Sulfonilureia
/
Vasodilatação
/
Vasodilatadores
/
Canais de Potássio
/
Ratos Wistar
/
Estreptozocina
/
Pinacidil
/
Sertralina
/
Diabetes Mellitus Experimental
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
2006
Tipo de documento:
Artigo
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