Influence of exogenous thymidine on killing and mutation of Chinese hamster V-79 cells by X-rays, ultraviolet light and N-methyl-N'-nitro-N-nitrosoguanidine.
Indian J Exp Biol
;
1989 May; 27(5): 437-41
Artigo
em Inglês
| IMSEAR
| ID: sea-58996
ABSTRACT
V-79 cells when exposed to thymidine (5 micrograms/ml) in growth medium after treatment with X-rays, UV light and N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), responded differently depending upon the agent. For treatment with X-rays and UV light, only induction of mutation was potentiated, but for MNNG treatment, both killing and mutation induction were potentiated. The increase in killing of MNNG exposed cells could be reversed by simultaneous addition of deoxycytidine with thymidine, but, for all the three mutagenic treatments, enhancement in mutation induction could not be suppressed by deoxycytidine.
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Índice:
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Assunto principal:
Timidina
/
Raios Ultravioleta
/
Masculino
/
Linhagem Celular
/
Sobrevivência Celular
/
Cricetulus
/
Cricetinae
/
Animais
/
Metilnitronitrosoguanidina
/
Mutação
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
1989
Tipo de documento:
Artigo
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