Pathogenesis of cerebral malaria.
Indian J Exp Biol
;
1991 Mar; 29(3): 267-71
Artigo
em Inglês
| IMSEAR
| ID: sea-59282
ABSTRACT
Plasmodium knowlesi infected rhesus monkeys were employed for investigating brain tissue damage in experimentally induced cerebral malaria. Light microscopic studies revealed parasitic infiltration of virtually all the regions of CNS. Electron microscopic observations confirmed the light microscopic findings. These studies further revealed the presence of macrophages in the blood vessels of infected monkeys. In conclusion, the pathogenesis of cerebral malaria seems to be an outcome of a typical triad consisting of (1) mechanical obstruction of the blood capillaries by parasitized RBCs; (2) biochemical events, involving free radicals, and (3) immunological dysfunction.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Encefalopatias
/
Microscopia Eletrônica
/
Animais
/
Macaca mulatta
/
Malária
Tipo de estudo:
Estudo de etiologia
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
1991
Tipo de documento:
Artigo
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