Effect of CDRI-85/287, a potent antiimplantation agent on uterine endometrial dimensions and peroxidase levels in rat.
Indian J Exp Biol
;
1998 May; 36(5): 464-9
Artigo
em Inglês
| IMSEAR
| ID: sea-59350
ABSTRACT
CDRI compound 85/287 a potent estrogen antagonist and antiimplantation agent in rat was studied to elucidate its mechanism of action. In ovariectomized rats 85/287 treatment antagonized estrogen stimulated uterine volume density, eosinophil leucocyte infiltration, stromal mitotic cell number and peroxidase activity. In parallel experiments in pregnant rats, uterine peroxidase activity also decreased significantly as compared to controls on day 5 post-coitum. The results show that 85/287 exerts its antiimplantation activity by inhibition of responses to estradiol action.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Implantação do Embrião
/
Peroxidases
/
Piperidinas
/
Ratos
/
Benzopiranos
/
Feminino
/
Gravidez
/
Ratos Sprague-Dawley
/
Endométrio
/
Antagonistas de Estrogênios
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
1998
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS