Hepatoprotective activity of Leucas hirta against CCl4 induced hepatic damage in rats.
Indian J Exp Biol
;
2005 Aug; 43(8): 722-7
Artigo
em Inglês
| IMSEAR
| ID: sea-59445
ABSTRACT
Methanol and aqueous leaf extracts of L. hirta demonstrated hepatoprotective activity against carbon tetrachloride induced liver damage in rats. The parameters studied were serum total bilirubin, total protein, alanine transaminase, aspartate transaminase and alkaline phosphatase activities. The hepatoprotective activity was also supported by histopathological studies of liver tissue. Results of the biochemical studies of blood samples of CCl4 treated animals showed significant increase in the levels of serum markers and decrease in total protein level reflecting the liver injury caused by CCl4. Whereas blood samples from the animals treated with methanol and aqueous leaf extracts showed significant decrease in the levels of serum markers and increase in total protein indicating the protection of hepatic cells. The results revealed that methanol leaf extract followed by aqueous extract of L. hirta could afford significant protection against CCl4 induced hepatocellular injury.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Ratos
/
Masculino
/
Tetracloreto de Carbono
/
Extratos Vegetais
/
Ratos Wistar
/
Folhas de Planta
/
Lamiaceae
/
Substâncias Protetoras
/
Doença Hepática Induzida por Substâncias e Drogas
/
Hepatite Animal
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
2005
Tipo de documento:
Artigo
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