Efficacy of 4-methyl-7-hydroxy coumarin derivatives against vectors Aedes aegypti and Culex quinquefasciatus.
Indian J Exp Biol
;
2008 Nov; 46(11): 788-92
Artigo
em Inglês
| IMSEAR
| ID: sea-59728
ABSTRACT
4-Methyl-7-hydroxy coumarin is considered as a lead molecule as a biopesticide. Its mono bromo and tribromo derivatives were synthesized. Two more derivatives were synthesized by acylation. Compound 1 (3,6,8-tribromo-7-hydroxy-4-methyl-chromen-2-one) was found to be the most potent against IVth instar larvae of C. quinquefasciatus and A. aegypti the LC50 being 1.49 and 2.23 ppm respectively. It showed 100% larval mortality at 25 ppm against A. aegypti and at 10 ppm against C. quinquefasciatus. Compounds 1 and 2 (3,6,8-tribromo-7-hydroxy-4-methyl-chromen-2'-oxo-2H-chromen-7-yl acetate) showed remarkable ovicidal activity. Significant reduction of 80-85% hatching of eggs of both mosquito species was observed at the highest dose of 100 ppm. The hatched larvae showed 100% mortality in the successive instars. Compounds 3 and 4 (3-bromo-7-hydroxy-4-methyl-chromen-2-one and 3-bromo-4-methyl-2'-oxo-2H-chromen-7-yl acetate) showed moderate activity against both mosquito species.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Praguicidas
/
Bioensaio
/
Resistência a Inseticidas
/
Himecromona
/
Espectroscopia de Ressonância Magnética
/
Desenho de Fármacos
/
Química Farmacêutica
/
Controle de Mosquitos
/
Aedes
/
Culex
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
2008
Tipo de documento:
Artigo
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