Effect of depot medroxyprogesterone acetate on testis of albino rats: ultrastructural and biochemical studies.
Indian J Exp Biol
;
1991 Apr; 29(4): 319-26
Artigo
em Inglês
| IMSEAR
| ID: sea-59874
ABSTRACT
Testis of male albino rats treated with depot medroxyprogesterone acetate DMPA, at the dose of 1 mg/animal/day for 60 days showed degenerative changes in the late spermatids. The changes were related with the mitochondrial sheath of the midpiece, including the plasma membrane enclosing the mitochondria and the mitochondrial cristae. Except lactate dehydrogenase and alkaline phosphatase, all the testicular marker enzymes, viz. beta-glucuronidase, hyaluronidase, sorbitol dehydrogenase and acid phosphatase registered a significant decrease. The ultrastructural and biochemical changes are correlated, as the cellular degeneration is responsible for decrease in the activity of the marker enzymes.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Ratos
/
Ratos Endogâmicos
/
Testículo
/
Feminino
/
Masculino
/
Acetato de Medroxiprogesterona
/
Anticoncepcionais Masculinos
/
Fertilidade
/
Animais
/
Medroxiprogesterona
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
1991
Tipo de documento:
Artigo
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