Involvement of p38 Mapkinase in attenuation of antinociceptive effect of morphine in diabetic mice.
Indian J Exp Biol
;
2007 Jul; 45(7): 654-6
Artigo
em Inglês
| IMSEAR
| ID: sea-59884
ABSTRACT
Experimental diabetes induced by streptozotocin (200 mg/kg, ip) markedly decreased the antinociceptive effect of morphine and significantly increased the urinary nitrite concentration. Administration of FR-167653 (a selective p38MAPKinase inhibitor) in a dose of 4 mg/kg improved the antinociceptive effect of morphine and attenuated the increase in urinary nitrite concentration in diabetic mice. It may be concluded that diabetes-induced decrease in antinociceptive effect of morphine may be due to induction of p38 MAPKinase activity.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Pirazóis
/
Piridinas
/
Glicemia
/
Feminino
/
Masculino
/
Desenho de Fármacos
/
Modelos Estatísticos
/
Inibidores de Ciclo-Oxigenase
/
Proteínas Quinases p38 Ativadas por Mitógeno
/
Analgésicos
Tipo de estudo:
Fatores de risco
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
2007
Tipo de documento:
Artigo
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