Changes in pancreatic beta cell function during growth and reproductive maturity of rats.
Indian J Exp Biol
;
1989 Jun; 27(6): 502-4
Artigo
em Inglês
| IMSEAR
| ID: sea-59982
ABSTRACT
An attempt has been made to study the changes, if any, in the efficiency of pancreatic beta cell function at different ages using one experimental model. For this, pancreatic islets were isolated from albino rats of 3, 8, 12 and 36 weeks of age and challenged with various concentrations of glucose (11.0, 16.7 and 22.2 mM). Significantly higher rate of glucose stimulated (pro)insulin biosynthesis was seen in the islets from 3 week old rats as compared to the islets obtained from 8, 12 and 36 week rats. On the other hand, immunoreactive insulin release was observed to be highest from islets of 8 week old rats followed by that of 12, 36 and 3 week old ones.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Proinsulina
/
Ratos
/
Maturidade Sexual
/
Masculino
/
Envelhecimento
/
Ilhotas Pancreáticas
/
Glucose
/
Insulina
/
Animais
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
1989
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS