Antinociceptive effect of amitriptyline in mice of acute pain models.
Indian J Exp Biol
;
2007 Jun; 45(6): 529-31
Artigo
em Inglês
| IMSEAR
| ID: sea-60128
ABSTRACT
Tricyclic antidepressant drugs induce antinociceptive effect and suggest that their analgesic action could be related to the monoaminergic activity of the drugs. The analgesic activity of amitriptyline was observed in mouse models of acute pain. Mice were divided into different groups and were given amitriptyline in different doses alone and in combination with morphine. Reaction time in Hot-Plate and Tail-Flick tests was observed. Results showed that amitriptyline had antinociceptive effect in acute pain state in experimental models. Amitriptyline in combination with morphine had better analgesic effect than the morphine alone in Hot-Plate test.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Dor
/
Doença Aguda
/
Analgésicos não Narcóticos
/
Modelos Animais de Doenças
/
Relação Dose-Resposta a Droga
/
Amitriptilina
/
Animais
/
Camundongos
Tipo de estudo:
Estudos de avaliação
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
2007
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS