Prevention of chromate induced oxidative stress by alpha-lipoic acid.
Indian J Exp Biol
;
2005 Jun; 43(6): 531-5
Artigo
em Inglês
| IMSEAR
| ID: sea-60259
ABSTRACT
The parenteral administration of alpha-lipoic acid (LA) protected against chromate induced oxidative stress in mouse liver. A shift in Cr induced pro-oxidant state to antioxidant-state by LA was noteworthy. The degree of protection was significant and similar in different LA administration regimens (prior-, co- and post- parenteral Cr exposure) explored. An improved status of the tissue antioxidants by LA appeared to be the mechanism of mitigation. The results are of chemopreventive value and suggest a possible alternative to ascorbic acid for abrogation of Cr toxicity.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Oxigênio
/
Dicromato de Potássio
/
Superóxido Dismutase
/
Fatores de Tempo
/
Masculino
/
Carbono
/
Peroxidação de Lipídeos
/
Catalase
/
Cromatos
/
Cromo
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
2005
Tipo de documento:
Artigo
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