Overexpression of c-erbB-2 oncoprotein and associated pathobiological factors in invasive primary breast cancer.
Indian J Exp Biol
;
2004 Mar; 42(3): 253-8
Artigo
em Inglês
| IMSEAR
| ID: sea-60340
ABSTRACT
Breast cancer tissues from 271 cases were analyzed immunologically for c-erbB-2 oncoprotein (HER-2/neu), epidermal growth factor receptor (EGF-R) and estrogen receptor (ER). Overexpression of both c-erbB-2 oncoprotein and EGF-R showed an inverse association with ER and a direct association with metastatic involvement of lymph node and high histological grade. The frequency of c-erbB-2 and EGF-R overexpression was significantly higher among postmenopausal cases in comparison with premenopausal cases. Further, only in postmenopausal patients, c-erbB-2 oncoprotein (chi2 = 6.4, P < 0.05) and EGF-R (chi2 = 6.4, p < 0.05) as well as their concomitant expression (chi2 = 11.5, p < 0.01) revealed a statistically significant association with ER.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Mama
/
Neoplasias da Mama
/
Idoso
/
Feminino
/
Humanos
/
Receptores de Estrogênio
/
Fatores Etários
/
Pré-Menopausa
/
Pós-Menopausa
/
Receptor ErbB-2
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
2004
Tipo de documento:
Artigo
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