Damage induction by direct electric current in tumoural target cells.
Indian J Exp Biol
;
2000 Jun; 38(6): 554-8
Artigo
em Inglês
| IMSEAR
| ID: sea-60353
ABSTRACT
Damage induction to tumour target cells (P815) by direct electric current (DC) was investigated. A 6 min treatment of P815 cells with DC generated decreased levels of cell viability and proliferation. The ultrastructural analysis of DC-treated cells revealed the presence of blebs, loss of cell surface filopodia, and ruptures in cell membrane. Mitochondrial alterations, swelling of cells, cytoplasmic matrix rarefaction, and cellular debri formation were also observed. The study shows that tumoural target cells can be damaged by direct electric current and this approach may provide means to understand the mechanism of tumour regression induced by electrochemical therapy.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Células Tumorais Cultivadas
/
Microscopia Eletrônica
/
Divisão Celular
/
Terapia por Estimulação Elétrica
/
Morte Celular
/
Sarcoma de Mastócitos
/
Eletricidade
/
Animais
/
Camundongos
Tipo de estudo:
Estudos de avaliação
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
2000
Tipo de documento:
Artigo
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