Analgesic and anti-inflammatory effects of phosphodiesterase inhibitors.
Indian J Exp Biol
;
2000 Jan; 38(1): 26-30
Artigo
em Inglês
| IMSEAR
| ID: sea-60380
ABSTRACT
The aim of the present study was to investigate the role of phosphodiesterase (PDE) enzyme inhibitors namely rolipram and theophylline in pain and inflammation in experimental animals. Rolipram, a selective PDE IV inhibitor and theophylline a nonspecific PDE inhibitor exerted dose dependent analgesic and anti-inflammatory effect against acetic acid-induced writhing in mice and carrageenan-induced paw edema in rats, respectively. Nimesulide (1, 2 mg/kg) produced significant anti-inflammatory effect. Further, nimesulide (0.5 mg/kg) potentiated analgesic effect of rolipram but it failed to modulate the anti-inflammatory effect of PDE inhibitors. Present study suggests that PDE enzymes might be playing a role in nociceptive and inflammatory responses in animals.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Dor
/
Inibidores de Fosfodiesterase
/
Sulfonamidas
/
Teofilina
/
Medição da Dor
/
Feminino
/
Masculino
/
Carragenina
/
Dor Abdominal
/
Anti-Inflamatórios não Esteroides
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
2000
Tipo de documento:
Artigo
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