Radioprotective effect of leaf extract of Indian medicinal plant Ocimum sanctum.
Indian J Exp Biol
;
1995 Mar; 33(3): 205-8
Artigo
em Inglês
| IMSEAR
| ID: sea-60394
ABSTRACT
Water or aqueous ethanol extract of O. sanctum was given ip, either as a single dose or multiple doses, before a whole-body exposure to 11 Gy(LD100/30) of 60Co gamma radiation in albino mice. The water extract was more effective and less toxic than the aqueous ethanol extract. An optimum ip dose of 50 mg/kg (< 1/100 LD50) of the water extract, at 10 mg/kg/day for 5 consecutive days, gave the maximum survival. Increasing the dose per treatment or the number of treatments did not increase protection. Intraperitoneal administration gave the best protection (70% survival). Other routes (im, iv and po) were less effective and produced 37-47% survival. The optimum dose (ip) gave a dose modifying factor of 1.28. Since the extract may contain a number of chemical compounds, it is not possible to attribute the observed protection to any particular compound at present.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Protetores contra Radiação
/
Extratos Vegetais
/
Vias de Administração de Medicamentos
/
Folhas de Planta
/
Ocimum basilicum
/
Animais
/
Camundongos
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
1995
Tipo de documento:
Artigo
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