Effect of ciprofloxacin on steady state pharmacokinetics of phenytoin in rabbits.
Indian J Exp Biol
;
1999 Jan; 37(1): 86-8
Artigo
em Inglês
| IMSEAR
| ID: sea-60411
ABSTRACT
Present study was undertaken to determine if an interaction exists during co-administration of ciprofloxacin with phenytoin. Eight healthy male rabbits received oral phenytoin, 40 mg/kg, od, for 7 days. On day 7, phenytoin blood sampling was done at times 0, 0.1, 1, 2, 3, 4, 5, 6, 8 and 24 hr. From day 8 to 14, phenytoin was co-administered with oral ciprofloxacin, 70 mg/kg, od. On day 14, blood samples were collected as previously described. Pharmacokinetic analysis revealed significant decrease in steady state maximum concentration (Cmax), through concentration (Cmin), elimination half life (t 1/2 e) and the area under plasma time concentration curve (AUC0-24) of phenytoin when co-administered with ciprofloxacin. It warrants close monitoring of levels when these two agents are given simultaneously.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Fenitoína
/
Coelhos
/
Masculino
/
Ciprofloxacina
/
Área Sob a Curva
/
Animais
/
Anti-Infecciosos
Tipo de estudo:
Estudo prognóstico
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
1999
Tipo de documento:
Artigo
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