FSH, the neglected sibling: evidence for its role in regulation of spermatogenesis and Leydig cell function.
Indian J Exp Biol
;
2005 Nov; 43(11): 993-1000
Artigo
em Inglês
| IMSEAR
| ID: sea-60465
ABSTRACT
The role of follicle stimulating harmone(FSH) in male reproductive function remains a matter of debate although recent evidences strongly suggest a role despite the controversies that arose following the results obtained with FSH-beta null mice and observations from human FSH receptor mutations. This review summarizes the recent developments of our understanding on the role of FSH in male reproduction. Specifically the results obtained with FSH-beta and FORKO null mice are be discussed in light of our observations employing active and passive neutralization of endogenous FSH in rodents and primates along with other studies. On the basis of results obtained employing a variety of models it can be conclude unequivocally that FSH regulates Leydig cell function and is essential for normal quantitative spermatogenesis.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Espermatogênese
/
Testosterona
/
Receptores do FSH
/
Humanos
/
Masculino
/
Camundongos Knockout
/
Hormônio Foliculoestimulante
/
Células Intersticiais do Testículo
/
Animais
/
Camundongos
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
2005
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS