Role of ATP-sensitive potassium channels in the piracetam induced blockade of opioid effects.
Indian J Exp Biol
;
2007 Dec; 45(12): 1050-4
Artigo
em Inglês
| IMSEAR
| ID: sea-60492
ABSTRACT
The present study has been designed to investigate the effect of piracetam on morphine/ buprenorphine-induced antinociception in rats and effect of piracetam on morphine or minoxidil induced relaxation in KCl-precontracted isolated rat aortic ring preparation. Nociceptive threshold was measured by the tail flick test in rats. The cumulative dose responses of morphine or minoxidil were recorded in KCl-precontracted isolated rat aortic ring preparation. Piracetam attenuated buprenorphine-induced antinociception in rats. Piracetam significantly reduced the morphine and minoxidil induced relaxation in KCl precontracted isolated rat aortic ring preparation suggesting that piracetam interferes with opioid receptor and ATP-sensitive potassium channel (KATP) opener mediated responses in vitro. Thus, it may be suggested that piracetam attenuates opioid effects by an opioid receptor-KATP channel linked mechanism.
Texto completo:
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Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Piracetam
/
Ratos
/
Masculino
/
Receptores Opioides
/
Peptídeos Opioides
/
Fármacos Neuroprotetores
/
Canais KATP
/
Analgésicos Opioides
/
Animais
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
2007
Tipo de documento:
Artigo
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