Phostoxin-induced biochemical and pathomorphological changes in rabbits.
Indian J Exp Biol
;
2004 Nov; 42(11): 1096-9
Artigo
em Inglês
| IMSEAR
| ID: sea-60526
ABSTRACT
The effect of chronic phostoxin administration on some tissue ATPases, hematology and tissue histopathology was investigated using a combination of gravimetric, enzymatic, colorimetric and histological procedures in New Zealand White rabbits after 2 weeks administration of 0.8mg phostoxin/kg body weight/day, po. The phostoxin treatment led to significant decreases in Na(+)-K+ ATPase activities in renal, hepatic and cardiac tissues. Similar decreases were obtained in the activities of Ca(2+)-ATPase and Mg(2+)-ATPase in liver. In addition, the phostoxin-toxified rabbits manifested significant decreases in hematocrit, red blood cell count, hemoglobin and platelets. Histological examination of the tissues revealed pronounced degenerative changes in liver, heart and kidney.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Praguicidas
/
Fosfinas
/
Coelhos
/
Poluentes Químicos da Água
/
ATPase de Ca(2/) e Mg(2/)
/
ATPases Transportadoras de Cálcio
/
Compostos de Alumínio
/
ATPase Trocadora de Sódio-Potássio
/
Contagem de Eritrócitos
/
Coração
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
2004
Tipo de documento:
Artigo
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