Methyl parathion induced alterations in GABAergic system during critical stage of central nervous system development in albino rat pups.
Indian J Exp Biol
;
1993 Apr; 31(4): 369-72
Artigo
em Inglês
| IMSEAR
| ID: sea-60639
ABSTRACT
Sublethal doses of methyl parathion (o, o-dimethyl-o-nitrophenyl thiophosphate) injected intraperitoneally to 7th day old developing albino rat pups induced alterations in the inhibitory GABAergic system of CNS. A substantial simulation of the inhibitory system was noticed. A profound increase was found in the level of the inhibitory transmitter, GABA on methyl parathion injection. An increase in the activity levels of the enzymes glutamic acid decarboxylase and 4-aminobutyrate-2-oxoglutarate-amino transferase in the cortex, brain stem and spinal cord of the CNS was found. It is observed that methyl parathion causes potentiation of the inhibitory transmission (GABAergic system) in the wake of inducing suppression of cholinergic system in CNS of developing rat pups.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Acetilcolinesterase
/
Ratos
/
Acetilcolina
/
Sistema Nervoso Central
/
Ácido gama-Aminobutírico
/
Glutamato Descarboxilase
/
4-Aminobutirato Transaminase
/
Animais
/
Animais Recém-Nascidos
/
Metil Paration
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
1993
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS