Evaluation of the modulatory influence of food additive-garam masala on hepatic detoxication system.
Indian J Exp Biol
;
1992 Dec; 30(12): 1142-5
Artigo
em Inglês
| IMSEAR
| ID: sea-60694
ABSTRACT
Potential chemopreventive role of an Indian food additive-garam masala has been assessed through its impact on the hepatic levels of detoxication enzymes like glutathione S-transferase (GST), cytochrome b5 (cyt. b5) and cytochrome P-450 (cyt. P-450), and acid soluble sulfhydryl (-SH) content in 8-9 weeks old Swiss albino mice of either sex fed on the 0.5%, 1.0% and 1.5% (w/w) garam masala in the diet for 10 days. The data from this short term study revealed the significant but dose-independent alteration in the levels of detoxication system enzymes. The results suggest the possible chemopreventive potency of this widely used food additive by being a bifunctional inducer of detoxication system.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Feminino
/
Masculino
/
Inativação Metabólica
/
Citocromos b5
/
Especiarias
/
Sistema Enzimático do Citocromo P-450
/
Aditivos Alimentares
/
Glutationa Transferase
/
Fígado
/
Animais
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
1992
Tipo de documento:
Artigo
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