Antitumor effect of cisplatin against murine ascites Dalton's lymphoma.
Indian J Exp Biol
;
1994 Mar; 32(3): 155-62
Artigo
em Inglês
| IMSEAR
| ID: sea-60765
ABSTRACT
Cisplatin treatment brings about complete regression of ascites Dalton's lymphoma in mice. In the present study various steps involved during the tumor regression are examined using some biochemical and morphological parameters. During tumor regression, ascites fluid volume decreases sharply and there is an increase in carbohydrates and decrease in protein contents in the ascites supernatant after cisplatin treatment in vivo. Cisplatin treatment brings about definite changes in the arrangement/movement of surface membrane ruffles/blebs of tumor cells and causes infiltration of leukocytes (neutrophils, monocytes, lymphocytes) towards tumor cells. Membrane vesicles and vacuoles are also formed before the disintegration and lysis of tumor cells.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Ascite
/
Células-Tronco Neoplásicas
/
Linfoma não Hodgkin
/
Indução de Remissão
/
Carboidratos
/
Microscopia Eletrônica de Varredura
/
Cisplatino
/
Animais
/
Camundongos
/
Proteínas de Neoplasias
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
1994
Tipo de documento:
Artigo
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