Involvement of dopamine D2 and 5-HT1A receptors in roxindole-induced antinociception.
Indian J Exp Biol
;
1999 Mar; 37(3): 234-7
Artigo
em Inglês
| IMSEAR
| ID: sea-60788
ABSTRACT
Roxindole, a DA D2 receptor agonist (2-16 mg/kg) produced dose-dependent increase in percentage antinociception. The effect which was blocked by DA D2 antagonist (-)sulpiride (50 mg/kg) and 5-HT1A receptor antagonist (-) pindolol (5 mg/kg). Roxindole (4 and 8 mg/kg) reversed both naloxone (20 mg/kg)-induced hyperalgesia and reserpine (2 mg/kg)-induced hyperalgesia. This reversal was sensitive to blockade by both (-)sulpiride (50 mg/kg) and (-) pindolol (5 mg/kg). The present study suggests that roxindole-induced antinociception is mediated by postsynaptic DA D2 and 5-HT1A receptors.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Pindolol
/
Piridinas
/
Reserpina
/
Sulpirida
/
Nociceptores
/
Receptores de Serotonina
/
Receptores de Dopamina D2
/
Agonistas de Dopamina
/
Receptores 5-HT1 de Serotonina
/
Analgésicos
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
1999
Tipo de documento:
Artigo
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