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Toxicities, LD50 prediction and in vivo neutralisation of some elapid and viperid venoms.
Indian J Exp Biol ; 1992 Dec; 30(12): 1158-62
Artigo em Inglês | IMSEAR | ID: sea-60948
ABSTRACT
Toxicity levels of elapid (Naja naja and Naja oxiana) viperid (Vipera lebetina and Vipera russelli) venoms for mice and rat for intraperitoneal intravenous and intramuscular routes have been determined. The data have been analysed using a mathematical expression to calculate lethal venom concentrations in human snake bite cases. Further, in vivo neutralisation of snake venom potency (after experimental injection) using high voltage-low current electric shock treatment has been attempted. This treatment postponed the death further by 60-90 min in mice in case of elapid envenomation. In case of viperid envenomation such a postponement of death time was not noticed. The death postponement induced by the shock treatment probably refers to structural impairments that occur at molecular level in venom components and their consequent altered interactions with the target tissue or system.
Assuntos
Texto completo: DisponíveL Índice: IMSEAR (Sudeste Asiático) Assunto principal: Coelhos / Ratos / Venenos de Víboras / Venenos Elapídicos / Cobaias / Dose Letal Mediana / Animais / Camundongos Tipo de estudo: Estudo prognóstico Idioma: Inglês Revista: Indian J Exp Biol Ano de publicação: 1992 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: IMSEAR (Sudeste Asiático) Assunto principal: Coelhos / Ratos / Venenos de Víboras / Venenos Elapídicos / Cobaias / Dose Letal Mediana / Animais / Camundongos Tipo de estudo: Estudo prognóstico Idioma: Inglês Revista: Indian J Exp Biol Ano de publicação: 1992 Tipo de documento: Artigo