Modulation of motor functions involving central dopaminergic system by L-histidine.
Indian J Exp Biol
;
2000 Oct; 38(10): 988-93
Artigo
em Inglês
| IMSEAR
| ID: sea-60965
ABSTRACT
There exists a possibility of interactions of histaminergic system with other neurotransmitters and their receptors in the central nervous system. Experimental evidences suggest a possible inhibitory influence of histaminergic system on the dopaminergic system. To elucidate the possible interaction between the histaminergic and dopaminergic pathways, we devised a strategy to study their effects on locomotor function and stereotypy behaviour. We investigated the effect of L-histidine, the precursor of histamine, on apomorphine-induced stereotypy and perphenazine-induced catalepsy. Histidine antagonised apomorphine-induced stereotypy. This inhibitory effect of histidine was abolished by both H1- and H2-receptor antagonists, chlorpheniramine and cimetidine, respectively. Perphenazine-induced catalepsy was potentiated by histidine and this effect was inhibited by chlorpheniramine alone but not by cimetidine. These results confirm a possible histamine-dopamine interaction in the modulation of motor functions by the central nervous system.
Texto completo:
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Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Ratos
/
Feminino
/
Masculino
/
Dopamina
/
Ratos Wistar
/
Histidina
/
Animais
/
Camundongos
/
Camundongos Endogâmicos BALB C
/
Atividade Motora
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
2000
Tipo de documento:
Artigo
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