Serotonin and benzylamine oxidation by type A and type B MAO of rat brain in presence of organophosphate pesticides.
Indian J Exp Biol
;
2001 Aug; 39(8): 802-6
Artigo
em Inglês
| IMSEAR
| ID: sea-61036
ABSTRACT
Organophosphate (OP) pesticides, monocrotophos (MCP), dichlorvos (DDVP) and phosphamidon significantly inhibit both MAO-A and MAO-B activities in rat brain mitochondria. The inhibition of MAO-A by MCP is reversible whereas the inhibition by DDVP and phosphamidon is irreversible. MAO-B is inhibited irreversibly by all these organophosphates suggesting that the mechanism of action of OP pesticides is through phosphorylation of serine residue present in active centre of MAO.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Compostos Organofosforados
/
Oxirredução
/
Ratos
/
Benzilaminas
/
Encéfalo
/
Masculino
/
Serotonina
/
Ratos Wistar
/
Inseticidas
/
Animais
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
2001
Tipo de documento:
Artigo
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