Your browser doesn't support javascript.
loading
Effect of gossypol on pituitary reproductive axis: ultrastructural and biochemical studies.
Indian J Exp Biol ; 1990 Aug; 28(8): 724-32
Artigo em Inglês | IMSEAR | ID: sea-61071
ABSTRACT
Oral administration of gossypol induced sterility in male rats by 10 weeks, at a dose of 15 mg/kg body weight/day. The pituitary FSH gonadotroph cells showed dilated endoplasmic reticulum and accumulation of secretory granules in the cytoplasm. LH cells were degranulated. The Leydig cells showed enhanced synthetic activity. There was no change in testis weight and testicular RNA, lipids and cholesterol in the treated group while significant increase was observed in DNA content. Testicular sialic acid content decreased significantly over controls. The Sertoli cells, spermatogonia, spermatocytes and early spermatids were not affected after the treatment. The weights of prostate, seminal vesicle were recorded normal and there were no ultrastructural variations. The levels of acid and alkaline phosphatase and RNA in prostatic tissue were insignificant as compared with controls. However, DNA content of prostate gland showed a significant increase. Sialic acid of seminal vesicle + coagulating gland were within the control range. A marked reduction in fructose values from the same organ was noted.
Assuntos
Texto completo: DisponíveL Índice: IMSEAR (Sudeste Asiático) Assunto principal: Tamanho do Órgão / Adeno-Hipófise / Próstata / Ratos / Glândulas Seminais / Testículo / Masculino / Gossipol / Administração Oral / Anticoncepcionais Masculinos Idioma: Inglês Revista: Indian J Exp Biol Ano de publicação: 1990 Tipo de documento: Artigo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: DisponíveL Índice: IMSEAR (Sudeste Asiático) Assunto principal: Tamanho do Órgão / Adeno-Hipófise / Próstata / Ratos / Glândulas Seminais / Testículo / Masculino / Gossipol / Administração Oral / Anticoncepcionais Masculinos Idioma: Inglês Revista: Indian J Exp Biol Ano de publicação: 1990 Tipo de documento: Artigo