Effect of verapamil post-treatment in myocardial reperfusion injury.
Indian J Exp Biol
;
1993 Feb; 31(2): 120-4
Artigo
em Inglês
| IMSEAR
| ID: sea-61138
ABSTRACT
Effect of verapamil post-treatment (0.2 mg/kg bolus, followed by 0.01 mg/kg/min infusion) on the functional and metabolic changes of the heart after a brief regional ischemia (20 min) followed by 1 hr of reperfusion was studied in open-chest pentobarbitone anaesthetized dogs. In control dogs 1 hr of reperfusion failed to cause any improvement of depressed myocardial contractility (LVdP/dtmax and LVEDP) caused by 20 min of ischemia, which confirmed the earlier reported phenomenon of 'Stunned Myocardium'. Myocardial ischemia caused a significant loss of high-energy phosphate (HEP) content of the affected myocardium (ATP decreased by 60% and CP decreased by 75% of non-ischemic level). Following 1 hr of reperfusion, myocardial ATP was not replenished, though creatine phosphate became near normal. When verapamil was administered just before reperfusion, it showed a profound beneficial effect on the incidence of fatal reperfusion arrhythmias. At the end of 1 hr of reperfusion in this group, the recovery of the myocardial contractility was incomplete, but a significant replenishment of the myocardial HEP content was observed. Thus verapamil post-treatment can prevent reperfusion-induced myocardial injury but functional recovery may be delayed due to the drug's inherent direct myocardial depressant effect.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Fibrilação Ventricular
/
Verapamil
/
Traumatismo por Reperfusão Miocárdica
/
Trifosfato de Adenosina
/
Creatina Quinase
/
Depressão Química
/
Cães
/
Animais
/
Contração Miocárdica
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
1993
Tipo de documento:
Artigo
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