Biochemical and histological studies on H2-receptor antagonist ranitidine-induced hepatotoxicity in rats.
Indian J Exp Biol
;
2005 Sep; 43(9): 782-5
Artigo
em Inglês
| IMSEAR
| ID: sea-61174
ABSTRACT
This study was designed to investigate the hepatotoxicity of ranitidine treatment in dose levels of 10, 30, and 50 mg/kg b.wt. for 3 weeks period in male rats. The results showed some adverse changes in rats treated with either 10 or 30 mg/kg. Treatment with dose of 50 mg/kg produced marked increase in the activity of both acid phosphatase in liver and aspartate aminotransferase in serum and liver, with a tendency for increase in serum alanine aminotransferase activity. Also, a significant decrease in the serum activity of both amylase and alkaline phosphatase was noted. Microscopic examination of livers of the same animals revealed absence of some hepatic cells, pyknotic nuclei, dilatation of blood sinusoids, binucleated cells, and infiltration of lymphocytes. These biochemical and histological changes indicate that ranitidine when given chronically in high dose could produce hepatotoxicity in rats.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Aspartato Aminotransferases
/
Ranitidina
/
Ratos
/
Fosfatase Ácida
/
Humanos
/
Masculino
/
Relação Dose-Resposta a Droga
/
Doença Hepática Induzida por Substâncias e Drogas
/
Antagonistas dos Receptores H2 da Histamina
/
Fígado
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
2005
Tipo de documento:
Artigo
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