Short-term zinc deficiency in diet induces increased oxidative stress in testes and epididymis of rats.
Indian J Exp Biol
;
2005 Sep; 43(9): 786-94
Artigo
em Inglês
| IMSEAR
| ID: sea-61222
ABSTRACT
In order to determine the effects of Zinc deficient diet on oxidative stress in testis and epididymis, various parameters viz total proteins, lipid peroxidation, hydroperoxides, antioxidant capacity and enzymatic activities are evaluated in rats fed on zinc deficient diet for 2, 4 and 6 weeks. Total proteins, water and lipid solouble antioxidant capacity decreased while lipid peroxidation (TBARS) and hydroperoxides concentration increased in testes, caput and cauda epididymis except in 2ZD (testes) where hydroperoxides revealed a significant decrease. GSH decreased in testes and caput and cauda epididymis. GPx and gamma-GT activities increased in testes and caput and cauda epididymis of zinc deficient rats. Further, GST increased in testes but exhibited decreases after 2 and 4 weeks and an increase after 6 weeks in caput and cauda epididymis of zinc deficient rats. GR activities decreased in testes but it increased in caput and cauda epididymis of zinc deficient rats. Thus, zinc deprivation results in increased sensitivity to oxidative stress. All these may have been as a consequence of increased ROS generation and/or decreased zinc dependent antioxidant processes.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Ratos
/
Testículo
/
Zinco
/
Masculino
/
Peroxidação de Lipídeos
/
Substâncias Reativas com Ácido Tiobarbitúrico
/
Espécies Reativas de Oxigênio
/
Ratos Wistar
/
Estresse Oxidativo
/
Epididimo
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
2005
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS